Email

jbwan@um.edu.mo

Tel

(853) 8822 4680

Office

N22-9007

Consultation Hours

Tue: 10:00-18:00
Wed: 10:00-18:00
Thu: 10:00-18:00

Jianbo WAN  萬建波

Professor

Deputy Director (Academic Affairs and Education)

Academic Qualifications

  • BSc., Wuhan University, Wuhan, China
  • MSc., China Pharmaceutical University, Nanjing China
  • MSc., University of Macau, Macao, China
  • PhD., University of Macau, Macao, China
  • Postdoctoral fellow, Massachusetts General Hospital and Harvard Medical School, Boston, USA

Teaching

CMED717Development of New Drugs and Health Products
CMED724Application of Pharmacokinetics and Metabonomics in Drug Development
CMED806Functional Food Product Development in Chinese Medicine

Research Interests

  • Chemical Derivatization Strategy for Mass Spectrometry-based Lipidomics and metabolomics.
  • Quality Evaluation of Chinese Medicines (Panax notoginseng roots and leaves).
  • Pharmacological Study on Chinese Medicines for the Prevention of Metabolic Diseases, including fatty liver

Dr. Jian-Bo Wan is currently a Professor at the Institute of Chinese Medical Sciences (ICMS) and The State Key Laboratory of Mechanism and Quality of Chinese Medicine, University of Macau. He received his B.S. degree in Pharmacy from Wuhan University in 2001, and his Ph.D. degree in Biomedical Sciences from the University of Macau in 2008. Then, he moved to Massachusetts General Hospital, an affiliated hospital of Harvard Medical School as a Postdoctoral Research Fellow from 2008 to 2011. His current research interest mainly focuses on quality research in Chinese Medicine, chemical derivatization strategy for mass spectrometry-based lipidomics and metabolomics, and pharmacological study on Chinese Medicines for the prevention of metabolic diseases, including fatty liver and atherosclerosis. Dr. Wan has published over 220 peer-reviewed SCI papers, including Nat. Commun., Acta Pharm. Sin. B, Chem. Eng. J., Redox Biol., Arterioscler. Thromb. Vasc. Biol., Anal. Chem., with a total citation of over 8,000 times and an H-index of 52 (web of science).

Book & Chapter

  1. Wan JB, Wang YT, Li SP. Panax notoginseng (Sanqi 三七). In Chinese herbs: Pharmacological Activities and Quality Control. Shaoping Li, Ed. Nova Science Publishers, Inc.: New York, 2008: 179-203. (ISBN: 978-1-60456-823-3).
  2. Wan JB, Chen Y, Li Ping, Huang WH, Zhang QW. Saponins from Panax Species: Chemistry, Isolation and Analysis. In: Saponins: Properties, Applications and Health Benefits. Rani Koh and Isaac Tay ed., Nova Science Publishers, Inc. New York, 2012: 51-98. (ISBN: 978-1-62100-942-9).
  3. Zhang XJ, Su HX, Wang YT, Wan JB*. Therapeutic Potential of Ginsenosides in Management of Atherosclerosis. In: Phytotherapies: Efficacy, Safety and Regulation. Iqbal Ramzan ed., Wiley, Inc. 2015: 236-2322258. (ISBN: 978-1-118-26806-3).
  4. Liu JY, Wan JB*. Omics in Quality Research of Chinese Medicines. In: Quality Control of Chinese Medicines – Strategies and Methods. Shaoping Li and Jing Zhao ed., Springer Singapore, 2024: 759–836. (ISBN: 978-981-99-9870-8).

Journals (Selected)

  1. Liu JY, Hua SY, Ma LJ, Tao X, Fu WY, Wan JB*. Deep eutectic solvents for ginsenoside extraction and inhibition of ginsenoside hydrolysis in Panax notoginseng leaves: methodology and mechanistic insights. Chem. Eng. J., 2025; 513: 162744.
  2. Ma LJ, Liu JY, Fu WY, Bi HC, Yuan D, Wan JB*. β-glucosidase mediates ginsenoside hydrolysis in the leaves of Panax species. Ind. Crops Prod., 2025; 226: 120636
  3. Shen H, Fu J, Liu J, Zou T, Wang K, Zhang XJ*, Wan JB*. Ginsenoside Rk2 alleviates hepatic ischemia/reperfusion injury by enhancing AKT membrane translocation and activation. , 2025; 6: e70047.
  4. Tao X, Liu JY, Zhou JY, Dai JK, Xiao Z, Li HK, Wan JB*. Girard Derivatization-Based Enrichment Strategy for Profiling the Carbonyl Submetabolome in Biological Samples. Anal Chem, 2024;96(52):20414-20424.
  5. Liu JY, Ma LJ, Yang RJ, Liu Y, Shu Z, Cai YQ, Zhang QW, Yang FQ*, Wan JB*. Preparation of Rare Dehydrated Protopanaxadiol Ginsenosides from Panax notoginseng Leaves by Confined Microwave-driven Transformation. J. Agric. Food Chem., 2025;73(1):678-692.
  6. Zhou JY, Chen YQ, Hu G, Zhao H, Wan JB*. An integrated strategy for in-depth profiling of N-acylethanolamines in biological samples by UHPLC-HRMS. Anal Chim Acta, 2024,1329:343262
  7. Chen ZQ, Yang RJ, Zhu CW, Li Y, Yan R, Wan JB*. Chemical Isotope Labeling and Dual-Filtering Strategy for Comprehensive Profiling of Urinary Glucuronide Conjugates. Anal Chem, 2024; 96:13576-13587
  8. Ma LJ, Liu X, Guo L, Luo Y, Zhang B, Cui X, Yang K, Cai J, Liu F, Ma N, Yang FQ, He X, Shi SP, Wan JB*. Discovery of plant chemical defence mediated by a two-component system involving β-glucosidase in Panax Nat. Commun., 2024; 15: 602.
  9. Zhang K, Jia J, Li T, Liu W, Tu P, Wan JB*, Li J*, Song Y*. Triple three-dimensional MS/MS spectrum facilitates quantitative ginsenosides-targeted sub-metabolome characterization in notoginseng. Acta Pharm Sin B. 2024; 14: 4045-4058
  10. Dai JK, Dan WJ, Cao YD, Gao JX, Wang JR, Wan JB*. Discovery of new quaternized norharmane dimers as potential anti-MRSA agents. J. Adv. Res., 2024; 63: 255-267.
  11. Zou J, Yang R, Feng R, Liu J, Wan JB*. Ginsenoside Rk2, a dehydroprotopanaxadiol saponin, alleviates alcoholic liver disease via regulating NLRP3 and NLRP6 inflammasome signaling pathways in mice. J. Pharm. Anal. 2023; 13: 999-1012.
  12. Yang RJ, Zou J, Liu JY, Dai JK, Wan JB*. Click chemistry-based enrichment strategy for tracing cellular fatty acid metabolism by LC-MS/MS. J. Pharm. Anal., 2023; 13: 1221-1231.
  13. Tian B, Liu J, Guo S, Li A, Wan JB*. Macromolecule-based hydrogels nanoarchitectonics with mesenchymal stem cells for regenerative medicine: A review. Int. J. Biol. Macromol., 2023; 243: 125161.
  14. Xia F, Wan JB*. Chemical derivatization strategy for mass spectrometry-based lipidomics. Mass Spectrom. Rev., 2023; 42: 432.
  15. Chen JF, Lu PD, Liu JY, Yang L, Li Y, Chen Y, Wang Y, Wan JB*, Zhao, YH*. 20(S)-Protopanaxadiol saponins isolated from Panax notoginseng target the binding of HMGB1 to TLR4 against inflammation in experimental ulcerative colitis. Phytother. Res. 2023; 37:4690.
  16. Lu PD, Chen JF, (…); Wan JB*, Zhao, YH*. 20(S)-Protopanaxadiol saponins isolated from Panax notoginseng target caveolin-1 against intestinal barrier dysfunction by alleviating inflammatory injury and oxidative stress in experimental murine colitis. Food Front., 2023, 4: 2081.
  17. Tian B, Liu J, Liu Y, Wan JB*. Integrating diverse plant bioactive ingredients with cyclodextrins to fabricate functional films for food application: a critical review. Crit. Rev. Food Sci. Nutr., 2022; 63: 7311-7340.
  18. Ma LJ, Ma N, Cao JL, Wan JB*. Characterizing the influence of different drying methods on chemical components of Panax notoginseng leaves by heart-cutting two-dimensional liquid chromatography coupled to orbitrap high-resolution mass spectrometry. Food Chem., 2022; 369: 130965.
  19. Chen YQ, Shen H, Yang RJ,Wan JB*. Accurate quantification of endogenous N-acylethanolamides by chemical isotope labeling coupled with liquid chromatography-tandem mass spectrometry. Chim. Acta, 2021; 1179: 338839.
  20. Li G, Liu H, Feng R, Kang TS, Wang W, Ko CN, Wong CY, Ye M, Ma DL, Wan JB*, Leung CH. A bioactive ligand-conjugated iridium (III) metal-based complex as a Keap1-Nrf2 protein-protein interaction inhibitor against acetaminophen-induced acute liver injury. Redox Biol., 2021; 48: 102129.
  21. Zuo X, Li Q, Ya F, Ma LJ, Tian Z, Zhao M, Fan D, Zhao Y, Mao YH, Wan JB*, Yang Y*. Ginsenosides Rb2 and Rd2 isolated from Panax notoginseng flowers attenuate platelet function through P2Y 12-mediated cAMP/PKA and PI3K/Akt/Erk1/2 signaling. Food Funct., 2021; 12: 5793.
  22. Zou J, Wang SP, Wang YT, Wan JB*. Regulation of the NLRP3 inflammasome with natural products against chemical-induced liver injury. Pharmacol. Res., 2021; 164: 105388
  23. Feng R, Ma LJ, Wang M, Liu C, Yang R, Su H, Yang Y, Wan JB*. Oxidation of fish oil exacerbates alcoholic liver disease by enhancing intestinal dysbiosis in mice. Biol., 2020; 3: 481.
  24. Ma LJ, Cao JL, Meng FC, Wang SP, Deng Y, Wang YT, Li P*, Wan JB*. Quantitative Characterization of Ginsenoside Biotransformation in Panax notoginseng Inflorescences and Leaves by Online Two-Dimensional Liquid Chromatography Coupled to Mass Spectrometry. Agric. Food Chem., 2020; 68: 8755.
  25. Xia F, He C, Ren M, Xu FG, Wan JB*. Quantitative profiling of eicosanoids derived from n-6 and n-3 polyunsaturated fatty acids by twin derivatization strategy combined with LC-MS/MS in patients with type 2 diabetes mellitus. Chim. Acta, 2020, 1120: 24-35.
  26. Xia F, Liu C, Wan JB*. Characterization of the cold and hot natures of raw and processed Rehmanniae Radix by integrated metabolomics and network pharmacology. Phytomedicine. 2019;74: 153071
  27. Xia F, Feng R, Xu FG, Su H, He C, Hu YJ, Wan JB*. Quantification of phospholipid fatty acids by chemical isotope labeling coupled with atmospheric pressure gas chromatography quadrupole-time-of-flight mass spectrometry (APGC/Q-TOF MS). Anal. Chim. Acta, 2019; 1082: 86-97
  28. Cao JL, Ma LJ, Wang SP, Deng Y, Wang YT, Li P, Wan JB*. Comprehensively qualitative and quantitative analysis of ginsenosides in Panax notoginseng leaves by online two-dimensional liquid chromatography coupled to hybrid linear ion trap Orbitrap mass spectrometry with deeply optimized dilution and modulation system. Anal. Chim. Acta, 2019; 1079: 237-251
  29. Feng R, Chen JH, Liu CH, Xia FB, Xiao Z, Zhang X, Wan JB*. A combination of Pueraria lobata and Silybum marianum protects against alcoholic liver disease in mice. Phytomedicine. 2019; 58: 152824
  30. Wang M, Ma LJ, Yang Y, Xiao Z, Wan JB*. n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review. Crit. Rev. Food Sci. Nutr., 2019; 59: S116.
  31. Feng R, Wang Y, Liu C, Yan C, Zhang H, Su H, Kang JX, Shang CZ, Wan JB*. Acetaminophen-induced Liver Injury is Attenuated in Transgenic fat-1 Mice Endogenously Synthesizing Long-chain n-3 Fatty Acids. Pharmacol., 2018 154, 75-88.
  32. Zhang M, Wang Y, Zhang Q, Wang C, Zhang D, Wan JB*, Yan C*. UPLC/Q-TOF-MS-based metabolomics study of the anti-osteoporosis effects of Achyranthes bidentata polysaccharides in ovariectomized rats. Int. J. Biol. Macromol., 2018; 112: 433-441.
  33. Fang Liu, Ni Ma, Fang-Bo Xia, Peng Li, Chengwei He, Zhenqiang Wu, Wan JB*, Preparative separation of minor saponins from Panax notoginseng leaves using biotransformation, macroporous resins and preparative high-performance liquid chromatography. J. Ginseng Res., 2019; 43: 105-115.
  34. Fang Liu, Ni Ma, Chengwei He, Yuanjia Hu, Peng Li, Meiwan Chen, Huanxing Su, Wan JB*, Qualitative and quantitative analysis of the saponins in Panax notoginseng leaves using ultra-performance liquid chromatography coupled with time-of-flight tandem mass spectrometry and high-performance liquid chromatography coupled with UV detector, J. Ginseng Res., 2018; 42: 149-157.
  35. Wang Y, Feng R, Wang R, Yang F, Li P, Wan JB*, Enhanced MS/MS coverage for metabolite identification in LC-MS-based untargeted metabolomics by target-directed data dependent acquisition with time-staggered precursor ion list. Anal. Chim. Acta, 2017; 992: 67.
  36. Wang M, Zhang X, Ma LJ, Feng RB, Yan C, Su H, He C, Kang JX, Liu B, Wan JB*, Omega-3 polyunsaturated fatty acids ameliorate ethanol-induced adipose hyperlipolysis: A mechanism for hepatoprotective effect against alcoholic liver disease. Biochim. Biophys. Acta, 2017; 1863: 3190.
  37. Wang Y, Liu F, Li P, He C, Wang R, Su H, Wan JB*. An improved pseudotargeted metabolomics approach using multiple ion monitoring with time-staggered ion lists based on ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry. Anal. Chim. Acta, 2016; 927: 82-8.
  38. Ding RB, Tian K, Cao YW, Bao JL, Wang M, He C, Hu Y, Su H, Wan JB*. Protective Effect of Panax notoginseng Saponins on Acute Ethanol-induced Liver Injury is Associated with Ameliorating Hepatic Lipid Accumulation and Reducing Ethanol-mediated Oxidative Stress. J. Agric. Food Chem., 2015; 63: 2413.
  39. Wan JB, Huang LL, Rong R, Tan R, Wang J, Kang JX. Endogenously decreasing tissue n-6/n-3 fatty acid ratio reduces atherosclerotic lesions in apolipoprotein E-deficient mice by inhibiting systemic and vascular inflammation. Arterioscler. Thromb. Vasc. Biol., 2010; 30: 2487.
  40. Wan JB; Zhang QW, Ye WC, Wang YT. Quantification and separation of protopanaxatriol and protopanaxadiol type saponins from Panax notoginseng with macroporous resins. Sep. Purif. Technol., 2008; 60: 198.

2024/2025Incentive Scheme for Outstanding Academic Staff in Research, University of Macau
2025Editorial Contribution Award 2025, Springer Nature
2025Author Service Award 2025, Springer Nature
2022/2023Outstanding Academic Staff Award, University of Macau
20211st Prize, 2020 International Award for Contribution to Chinese Medicine – Achievement Award in Medical Science, World Federation of Chinese Medicine Societies (3rd author)
2020-2024World’s Top 2% Scientists 2020
2018ICMS Outstanding Academic Staff Award, University of Macau

  • Member of Academic Committee, Key Laboratory for Marine Chinese Medicine Quality Research and Evaluation, National Medical Products Administration
  • Member of Executive Council, Specialty Committee of Li Shizhen Medicine, World Federation of Chinese Medicine Societies
  • Executive Council Member, Specialty Committee of Chinese Medicine Healthcare Products, World Federation of Chinese Medicine Societies
  • President of a Council, International Association of Quality Research in Chinese Medicine
  • Member of Chinese Medicine Professional Committee of Chinese Society of Integrated Medicine
  • Youth member, Analytical Pharmacology Committee of Chinese Pharmacological Society
  • Member, Macau Product Quality Certification Commission
  • Youth member, Pharmaceutical Analysis Technology Branch of China Medical Biotechnology Association

  • Deputy Editor, Chinese Medicine (https://cmjournal.biomedcentral.com/)
  • Youth Editorial Board Member, Journal of Pharmaceutical Analysis.
  • Youth Editorial Board Member, Chinese Journal of Natural Medicines
  • Youth Editorial Board Member, Journal of Analysis and Testing.
  • Editorial Board Member, World science and Technology – Modernization of Traditional Chinese Medicine and Materia Medica
  • Guest Editors for Molecules, Chinese Medicine and Evidence-Based Complementary and Alternative Medicine
  • Grant Reviewer for National Science Foundation of China (NSFC)