Email

swang@um.edu.mo

Tel

(853) 8822 8559

Office

N22-8035

Consultation Hours

Mon: 14:00-17:00
Thu: 14:00-17:00

Shengpeng WANG 王勝鵬

Assistant Professor

Assistant Director (State Key Laboratory of Mechanism and Quality of Chinese Medicine)

Deputy Director (Industry-Academia Collaboration) of Macao Centre for Research and Development in Chinese Medicine

Academic Qualifications

  • PhD. in Biomedical Sciences, University of Macau, Macao
  • BSc. in Chinese Materia Medica (National Basic Scientific Research & Teaching Personnel Training Base), Chengdu University of Traditional Chinese Medicine, Chengdu, China

Teaching

  1. CMED8005 Quality Research in Chinese Medicine (Ph.D. Course)
  2. CMED8003 Functional Food Product Development in Chinese Medicine (Ph.D. Course)
  3. CMED7005 International Business and Law for Medicine (Master Course)
  4. HSCI2012 Analytical Chemistry Lab (Undergraduate Course)

Research Interests

  • Structure-activity relationship of natural polysaccharides
  • Development of novel delivery systems and novel products of Chinese medicine

Selected Publications

Representative peer-reviewed journal papers (h-index 52, * co-/corresponding author;  # co-first author)

  1. Chen Y, Shui MJ, Li HY, Guo M, Yuan Q, Hao W, Wang T, Zhou HF, Chen ZJ, Wang SP*. Inflammation-targeted delivery of probiotics for alleviation of colitis and associated cognitive disorders through improved vitality and colonization. Biomaterials. 2025; 318:123163.
  2. Xiao YQ, Zhao QY, Ni DW, Zhang XQ, Hao W, Yuan Q, Xu W, Mu WM, Wu DT, Wu X*, Wang SP*. Polymerization of dietary fructans differentially affects interactions among intestinal microbiota of colitis mice. The ISME Journal. 2025; 19:wrae262.
  3. Yuan Q, Liu W, Wu HK, Yang XP, Li HY, Chen Y, Shui MJ, Ding Y, Wang SP*. Fructans with various molecular weights from Polygonatum cyrtonema Hua differentially ameliorate intestinal inflammation by regulating the gut microbiota and maintaining intestinal barrier. International Journal of Biological Macromolecules. 2025; 285:138359.
  4. Wang Y, Jiang Y, Li MX, Xiao YQ, Zhao QY, Zeng JP, Wei SL, Chen SH, Zhao YS, Du FK, Chen Y, Deng S, Shen J, Li XB, Li WP, Wang F, Sun YH, Gu L, Xiao ZG, Wang SP*, Wu X*. Rosavin derived from Rhodiola alleviates colitis in mice through modulation of Th17 differentiation. Phytomedicine. 2025; 136:156318.
  5. Yuan Q, Liu W, Hao W, Chen Y, Xiao YQ, Li HY, Shui MJ, Wu DT*, Wang SP*. Glycosidic linkages of fungus polysaccharides influence the anti-inflammatory activity in mice. Journal of Advanced Research. 2025; 67:161-172.
  6. Wang XJ, Zhang GH, Bian ZW, Chow V, Grimaldi M, Carivenc C, Sirounian S, Li H, Sladekova L, Motta S, Luperi Y, Gong Y, Costello C, Li LH, Jachimowicz M, Guo M, Hu SA, Wilson D, Balaguer P, Bourguet W, Mani S, Bonati L, Peng H, March J, Wang HB, Wang SP*, Krause HM*, Liu JB*. An abundant ginger compound furanodienone alleviates gut inflammation via the xenobiotic nuclear receptor PXR in mice. Nature Communications. 2025; 16:1280.
  7. Liu XY, Bian ZW, Hu SA, Dickinson CF, Benjamin MM, Jia J, Tian YT, Place A, Hanna GS, Luesch H, Croot P, Reddy MM, Thomas OP, Hardiman G, Puglisi MP, Yang M, Zhong Z, Lemasters JJ, Korte JE, Waters AL, Heltzel CE, Williamson RT, Strangman WK, Valeriote F, Tius MA, DiTullio GR, Ferreira D, Alekseyenko A, Wang SP*, Hamann MT*, Wang XJ*. The Chemistry of Phytoplankton. Chemical Reviews. 2024; 124:13099-13177.
  8. Liu W, Yuan Q, Li HY, He HT, Ren T, Wu DT, Wang SP*, Chen XJ*. Fructo-oligosaccharides and polyfructans derived from Ophiopogon japonicus ameliorate experimental colitis by regulating the gut microbiota. Carbohydrate Polymer Technologies and Applications. 2024; 8:100602.
  9. Xu YD, Chen ZJ, Hao W, Yang ZM, Farag M, Vong CT, Wang YT*, Wang SP*. Berberine and magnolol exert cooperative effects on ulcerative colitis in mice by self-assembling into carrier-free nanostructures. Journal of Nanobiotechnology. 2024; 22:538.
  10. Luo HM, Guo M, Li MX, Zhao YS, Shen J, Du FK, Chen Y, Deng S, Sun YH, Gu L, Li WP, Li XB, Chen MJ, Xiao ZG, Wang SP*, Wu X*. Protective effect of rosavin against intestinal epithelial injury in colitis mice and intestinal organoids. Journal of Inflammation Research. 2024; 17:6023-6038.
  11. Bian ZW, Liu XY, Hu SA, Li HY, Wood JS, Williamson RT, Liu JB, Chen Y, Shi J, Cummins CL, Ferreira D, Choo YM, Wang SP*, Hamann MT*, Wang XJ*. Computationally-assisted discovery and assignment of a new class of 6/6/5/5 fused-ring diterpene acting as pregnane X receptor ligands from Isodon serra. Journal of Natural Products. 2024; 87:2459-2467.
  12. Liu W, Wang LJ, Yuan Q, Hao W, Wang YT, Wu DT, Chen XJ*, Wang SP*. Agaricus bisporus polysaccharides ameliorate ulcerative colitis in mice by modulating gut microbiota and its metabolism. Food & Function. 2024; 15:1191-1207.
  13. Chen Y, Shui MJ, Yuan Q, Li HY, Zhou HF, Wang YT, Chen ZJ*, Wang SP*. Oral chondroitin sulfate functionalized natural polyphenol for targeted therapy of ulcerative colitis. Materials & Design. 2024; 238:112645.
  14. Chen ZJ, Chen Y, Hao W, Shui MJ, Zhang JM, Zhou HF, Zhang C, Wang YT*, Wang SP*. Oral delivery of transformable bilirubin self-assembled system for targeted therapy of colitis. Advanced Healthcare Materials. 2023; 12:e2300946.
  15. Yuan Q, Liu W, Huang L, Wang LJ, Yu J, Wang YT, Wu DT*, Wang SP*. Quality evaluation of immunomodulatory polysaccharides from Agaricus bisporus by an integrated fingerprint technique. Food Frontiers. 2023; 4:474-490.
  16. Shui MJ, Chen ZJ, Chen Y, Yuan Q, Li HY, Vong CT, Farag MA*, Wang SP*. Engineering polyphenol-based carriers for nucleic acid delivery. Theranostics. 2023; 13:3204-3223.
  17. Wang ML, Zhang HL, Yi LZ, Högger P, Arroo R, Bajpai VK, Prieto MA, Simal-Gandara J, Wang SP*, Cao H*. Stability and antioxidant capacity of epigallocatechin gallate in Dulbecco’s modified eagle medium. Food Chemistry. 2022; 366:130521.
  18. Hao W, Chen ZJ, Wang LJ, Yuan Q, Gao CF, Ma ML, Liu CS, Wang YT*, Wang SP*. Classical prescription Huanglian Decoction relieves ulcerative colitis via maintaining intestinal barrier integrity and modulating gut microbiota. Phytomedicine: international journal of phytotherapy and phytopharmacology. 2022; 107:154468.
  19. Li HY, Wang Y, Shao SM, Yu H, Wang DQ, Li CY, Yuan Q, Liu W, Cao JL, Wang XJ, Guo HB, Wu X*, Wang SP*. Rabdosia serra alleviates dextran sulfate sodium salt-induced colitis in mice through anti-inflammation, regulating Th17/Treg balance, maintaining intestinal barrier integrity, and modulating gut microbiota. Journal of Pharmaceutical Analysis. 2022; 12:824-838.
  20. Gao CF, Zhou YY, Chen ZJ, Li HY, Xiao YQ, Hao W, Zhu Y, Vong CT, Farag MA, Wang YT*, Wang SP*. Turmeric-derived nanovesicles as novel nanobiologics for targeted therapy of ulcerative colitis. Theranostics. 2022; 12:5596-5614.
  21. Hao W, Chen ZJ, Yuan Q, Ma ML, Gao CF, Zhou YY, Zhou HF, Wu X, Wu DT, Farag MA, Wang SP*, Wang YT*. Ginger polysaccharides relieve ulcerative colitis via maintaining intestinal barrier integrity and gut microbiota modulation. International Journal of Biological Macromolecules. 2022; 219:730-739.
  22. Chen ZJ, Hao W, Gao CF, Zhou YY, Zhang C, Zhang JM, Wang RB, Wang YT*, Wang SP*. A polyphenol-assisted IL-10 mRNA delivery system for ulcerative colitis. Acta Pharmaceutica Sinica. B. 2022; 12:3367-3382.
  23. Zhou YY, Gao CF, Vong CT, Tao HX, Li HY, Wang SP*, Wang YT*. Rhein regulates redox-mediated activation of NLRP3 inflammasomes in intestinal inflammation through macrophage-activated crosstalk. British Journal of Pharmacology. 2022; 179:1978-1997.
  24. Chen SY, Chen ZJ, Wang Y, Hao W, Yuan Q, Zhou HF, Gao CF, Wang YT, Wu X*, Wang SP*. Targeted delivery of Chinese herb pair-based berberine/tannin acid self-assemblies for the treatment of ulcerative colitis. Journal of Advanced Research. 2022; 40:263-276.
  25. Wang AQ, Liu JY, Yang YH, Chen ZJ, Gao CF, Wang ZG, Fu CM, Zou L*, Wang SP*. Shikonin promotes ubiquitination and degradation of cIAP1/2-mediated apoptosis and necrosis in triple negative breast cancer cells. Chinese Medicine. 2021; 16:16.
  26. Chen ZJ, Farag MA, Zhong ZF, Zhang C, Yang Y, Wang SP*, Wang YT*. Multifaceted role of phyto-derived polyphenols in nanodrug delivery systems. Advanced Drug Delivery Reviews. 2021; 176:113870.
  27. Li XZ, Chen WJ, Simal-Gandara J, Georgiev MI, Li HY, Hu H, Wu X, Efferth T, Wang SP*. West meets east: open up a dialogue on phytomedicine. Chinese Medicine. 2021; 16:57.
  28. Chen WJ, Li XZ, Chen ZJ, Hao W, Yao PF, Li M, Liu KM, Hu H, Wang SP*, Wang YT*. A comprehensive quality analysis of randomized controlled clinical trials of Asian ginseng and American ginseng based on the CONSORT guideline. Journal of Ginseng Research. 2022; 46:71-78.
  29. Wang Y, Tao HX, Huang HM, Xiao YQ, Wu XX, Li MX, Shen J, Xiao ZG, Zhao YH, Du FK, Ji HJ, Chen Y, Cho CH, Wang YT, Wang SP*, Wu X*. The dietary supplement Rhodiola crenulata extract alleviates dextran sulfate sodium-induced colitis in mice through anti-inflammation, mediating gut barrier integrity and reshaping the gut microbiome. Food & Function, 2021; 12:3142-3158.
  30. Chen WJ, Yao PF, Vong CT, Li XZ, Chen ZJ, Xiao JB, Wang SP*, Wang YT*. Ginseng: A bibliometric analysis of 40-year journey of global clinical trials. Journal of Advanced Research. 2020; 34:187-197.
  31. Chen ZJ, Liu LJ, Gao CF, Chen WJ, Vong CT, Yao PF, Yang YH, Li XZ, Tang XD, Wang SP*, Wang YT*. Astragali Radix (Huangqi): A promising edible immunomodulatory herbal medicine. Journal of Ethnopharmacology. 2020; 258:112895.
  32. Wu X, Cao JL, Li MX, Yao PF, Li HY, Xu WD, Yuan C, Liu JY, Wang SP*, Li P*, Wang YT. An integrated microbiome and metabolomic analysis identifies immunoenhancing features of Ganoderma lucidum spores oil in mice. Pharmacological Research. 2020; 158:104937.
  33. Tao HX, Wu X, Cao JL, Peng Y, Wang AQ, Pei J, Xiao JB, Wang SP*, Wang YT*. Rhodiola species: A comprehensive review of traditional use, phytochemistry, pharmacology, toxicity, and clinical study. Medicinal Research Reviews. 2019; 39:1779-1850.
  34. Wu X, Wang SP*, Lu JR, Jing Y, Li MX, Cao JL, Bian BL, Hu CJ. Seeing the unseen of Chinese herbal medicine processing (Paozhi): advances in new perspectives. Chinese Medicine. 2018; 13:4.
  35. Wang SP, Xu YQ, Li CY, Tao HX, Wang AQ, Sun CY, Zhong ZF, Wu X, Li P, Wang YT. Gambogic acid sensitizes breast cancer cells to TRAIL-induced apoptosis by promoting the crosstalk of extrinsic and intrinsic apoptotic signalings. Food and Chemical Toxicology. 2018; 119:334-341.
  36. Wu X#, Wang SP#, Li MX, Wang AQ, Zhou YY, Li P, Wang YT*. Nanocarriers for TRAIL delivery: driving TRAIL back on track for cancer therapy. Nanoscale. 2017; 9:13879-13904.
  37. Wang SP, Wang AQ, Shao M, Lin LG, Li P, Wang YT. Schisandrin B reverses doxorubicin resistance through inhibiting P-glycoprotein and promoting proteasome-mediated degradation of survivin. Scientific Reports. 2017; 7:8419.
  38. Wang SP, Shao M, Zhong ZF, Wang AQ, Cao JL, Lu YC, Wang YT*, Zhang JM. Co-delivery of gambogic acid and TRAIL plasmid by hyaluronic acid grafted PEI-PLGA nanoparticles for the treatment of triple negative breast cancer. Drug Delivery. 2017; 24:1791-1800.
  39. Wang SP, Zhang JM, Wang YT*, Chen MW*. Hyaluronic acid-coated PEI-PLGA nanoparticles mediated co-delivery of doxorubicin and miR-542-3p for triple negative breast cancer therapy. Nanomedicine-Nanotechnology Biology and Medicine. 2016; 12:411-420.
  40. Wang SP, Xu YQ, Chan HF, Kim HW, Wang YT, Leong KW, Chen MW*. Nanoparticle-mediated inhibition of survivin to overcome drug resistance in cancer therapy. Journal of Controlled Release. 2016; 240:454-464.
  41. Wang SP, Yang Y, Wang YT*, Chen MW*. Gambogic acid-loaded pH-sensitive mixed micelles for overcoming breast cancer resistance. International Journal of Pharmaceutics. 2015; 495:840-848.
  42. Wang SP, Qiu JG, Shi Z, Wang YT, Chen MW*. Nanoscale drug delivery for taxanes based on the mechanism of multidrug resistance of cancer. Biotechnology Advances. 2015; 33:224-241.
  43. Wang SP, Chen R, Morott J, Repka MA, Wang YT, Chen MW. mPEG-b-PCL/TPGS mixed micelles for delivery of resveratrol in overcoming resistant breast cancer. Expert Opinion on Drug Delivery. 2015; 12:361-373.
  44. Hu YY#, Wang SP#, Wang AQ, Lin LG, Chen MW, Wang YT. Antioxidant and Hepatoprotective Effect of Penthorum chinense Pursh Extract against t-BHP-Induced Liver Damage in L02 Cells. Molecules. 2015; 20:6443-6453.
  45. Wang SP, Wang L, Chen MW, Wang YT. Gambogic acid sensitizes resistant breast cancer cells to doxorubicin through inhibiting P-glycoprotein and suppressing survivin expression. Chemico-Biological Interactions. 2015; 235:76-84.
  46. Wang SP, Wang L, Shi Z, Zhong ZF, Chen MW*, Wang YT*. Evodiamine Synergizes with Doxorubicin in the Treatment of Chemoresistant Human Breast Cancer without Inhibiting P-Glycoprotein. Plos One. 2014; 9:e97512.
  47. Wang SP, Chen RE, Zhong ZF, Shi Z, Chen MW*, Wang YT*. Epigallocatechin-3-Gallate potentiates the effect of curcumin in inducing growth inhibition and apoptosis of resistant breast cancer cells. American Journal of Chinese Medicine. 2014; 42:1279-1300.
  48. Wang SP, Zhong ZF, Wan JB, Tan W, Wu GS, Chen MW, Wang YT*. Oridonin induces apoptosis, inhibits migration and invasion on highly-metastatic human breast cancer cells. American Journal of Chinese Medicine. 2013; 41:177-196.
  49. Wang SP, Zhang JM, Chen MW, Wang YT. Delivering flavonoids into solid tumors using nanotechnologies. Expert Opinion on Drug Delivery. 2013; 10:1411-1428.
  50. Hu YY#, Wang SP#, Wu X, Zhang JM, Chen R, Chen MW, Wang YT. Chinese herbal medicine-derived compounds for cancer therapy: A focus on hepatocellular carcinoma. Journal of Ethnopharmacology. 2013; 149:601-612.
  51. Wang SP, Wu X, Tan M, Gong J, Tan W, Bian BL, Chen MW, Wang YT*. Fighting fire with fire: Poisonous Chinese herbal medicine for cancer therapy. Journal of Ethnopharmacology. 2012; 140:33-45.
  52. Wang SP, Hu YY, Tan W, Wu X, Chen RE, Cao JL, Chen MW, Wang YT*. Compatibility art of traditional Chinese medicine: From the perspective of herb pairs. Journal of Ethnopharmacology. 2012; 143:412-423.
  53. Wang SP, Chen TK, Chen RE, Hu YY, Chen MW, Wang YT*. Emodin loaded solid lipid nanoparticles: Preparation, characterization and antitumor activity studies. International Journal of Pharmaceutics. 2012; 430:238-246.
  54. Wang SP, Tan M, Zhong ZF, Chen MW, Wang YT*. Nanotechnologies for curcumin: an ancient puzzler meets modern solutions. Journal of Nanomaterials. 2011; 723178.
  55. Chen MW#, Wang SP#, Tan M, Wang YT*. Applications of nanoparticles in herbal medicine: zedoary turmeric oil and its active compound beta-elemene. American Journal of Chinese Medicine. 2011; 39:1093-1102.

Book Chapters

  1. Wang SP, Chen MW, Zhou Q, Chan HK. Novel formulations and drug delivery systems for phytotherapies. In: Phytotherapies: Efficacy, Safety and Regulation. Iqbal Ramzan ed., John Wiley & Sons, Inc., 2014. (ISBN: 978-1-118-26806-3).
  2. Wang SP et al. Novel drug delivery systems for Chinese medicine. In: Modern technology and progress on anti-tumor Chinese medicine. YT Wang ed., People’s Medical Publishing House, Beijing, 2012. (ISBN: 978-7-117-16227-2).

  1. Wang SP, Zhang GH. A Natural PXR agonist and its Application in Colitis. China, CN119405649A, 2025.
  2. Wang SP, Xiao YQ. Application of Dubosiella newyorkensis for inflammatory bowel disease. China, CN116747244A. 2023.
  3. Wang YT, LI P, Yu H, Wang CM, Wang SP, Zhang JM. Development of solid-liquid capsules for Chinese medicine. China, CN106963742A. 2016.

Member, International Society for Chinese Medicine

Member, Specialty Committee of New Drug Development of Chinese Medicine of World Federation of Chinese Medicine Societies

Member, International Natural Product Sciences Taskforce

Guest editor of Chinese Medicine.

Youth Editorial Member of Journal of Pharmaceutical Analysis and Acupuncture and Herbal Medicine.

Ad-hoc reviewer of more than 35 academic journals including Advanced Research, Gut Microbes, Acta Pharmaceutica Sinica B, Advanced Drug Delivery Reviews, British Journal of Pharmacology, Carbohydrate Polymers, Journal of Advanced Research, Advanced Healthcare Materials, Theranostics, Phytomedicine, and Journal of Ethnopharmacology.