Email

shaoyizhang@um.edu.mo

Tel

+853 8822 8785

Office

N22-1014

Consultation Hours

Tue: 11:00-12:00
Thu: 11:00-12:00

Shaoyi ZHANG 張少一

Assistant Professor

Academic Qualifications

  • Postdoctoral Scholar, University of California, San Francisco, USA (2025)
  • Ph.D. in Life Sciences, University of Paris-Saclay, Paris, France (2018)
  • Master of Clinical Medicine, Nanjing University, Nanjing, China (2014)
  • Bachelor of Medicine (with a minor in Law), Southern Medical University, Guangzhou, China (2011)

Research Interests

Prof. Shaoyi Zhang is currently an Assistant Professor at the Institute of Chinese Medical Sciences and a Principal Investigator at the State Key Laboratory of Mechanism and Quality of Chinese Medicine, University of Macau. With dual training in clinical medicine (M.D.) and biomedical sciences (Ph.D.), he has conducted research in cell death, immunology, and intestinal stem cell biology at Université Paris-Saclay in France and the University of California, San Francisco (UCSF) in the United States. He also completed his standardized surgical residency training at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, and is certified as an attending surgeon in China.
Prof. Zhang’s translational and basic research findings have been published in leading international journals such as Nature, Gastroenterology, and Cell Host & Microbe. His lab focuses on intestinal stem cells, organoid-based disease modeling, transcriptional regulation, gut injury and regeneration, and the gut microbiota–immune microenvironment interface, aiming to develop novel therapeutic strategies for clinically relevant diseases.

  • Gut microbiota as a potential therapeutic target for immune checkpoint inhibitor-related toxicity，State Key Laboratory of Mechanism and Quality of Chinese Medicine, University of Macau，2025，PI
  • Transcriptional regulation of intestinal stem cell fate and regeneration using organoid and gene editing models，State Key Laboratory of Mechanism and Quality of Chinese Medicine, University of Macau，2025，PI
  • Mechanism study of cysteamine combined with EGCG synergistically regulating autophagy and affecting CFTR membrane transport in the treatment of chronic pancreatitis, (NSFC.82100677), 2022-2025, PI
  • Chemosensitization of pancreatic cancer induced by caloric restriction analogs regulating autophagy pathway, (Shanghai Science and Technology Commission: Shanghai Sailing Program,19YF1431000) 2019-2022, PI

  1. Chen Q, Wu C, Xu J, Ye C, Chen X, Tian H, Zong N, Zhang S, Li L, Gao Y, Zhao D. Donor-recipient intermicrobial interactions impact transfer of subspecies and fecal microbiota transplantation outcome. Cell Host & Microbe. 2024 Feb 12.
  2. Qin, J., Zhang, S., Munir, A., Chen, Y. C., Zhang, K., Li, J., … & Moslehi, J. (2023). Abstract P2174: Transcriptomic Profiling Of Immune Checkpoint Inhibitor Myocarditis Reveals Novel Therapeutic Targets. Circulation Research, 133(Suppl_1), AP2174-AP2174.
  3.  Axelrod, M. L., Meijers, W. C., Screever, E. M., Qin, J., Carroll, M. G., Sun, X., Zhang, S & Balko, J. M. “T cells specific for α-myosin drive immunotherapy-related myocarditis.” Nature (2022): 1-9.
  4.  Pu W, Su Z, Wazir J, Zhao C, Wei L, Wang R, Chen Q, Zheng S, Zhang S, Wang H. Protective effect of α7 nicotinic acetylcholine receptor activation on experimental colitis and its mechanism. Molecular Medicine. 2022 Dec;28(1):1-7. Corresponding author
  5. Tian H, Zhang S, Qin H, Li N, Chen Q. Long-term safety of faecal microbiota transplantation for gastrointestinal diseases in China. The Lancet Gastroenterology & Hepatology. 2022 Aug 1;7(8):702-3.
  6. Zhang, S., Chen, Q., Kelly, C. R., Kassam, Z., Qin, H., Li, N., & Shanghai Tongji FMT Working Group.(2022). Donor screening for fecal microbiota transplantation in China: Evaluation of 8483 candidates. Gastroenterology, 162(3), 966-968. First author
  7. Di Zhao, Chen Ye, Shaoyi Zhang, Xiaoqiong Lv, and Bo Yang. “Analysis of risk factors for early clinical recurrence of inflammatory bowel disease after fecal microbiota transplantation.” American Journal of Translational Research13, no. 11 (2021): 12875.
  8. Zhao, Di, Bo Yang, Chen Ye, Shaoyi Zhang, Xiaoqiong Lv, and Qiyi Chen. “Enteral nutrition ameliorates the symptoms of Crohn’s disease in mice via activating special pro-resolving mediators through innate lymphoid cells.” Innate Immunity 27, no. 7-8 (2021): 533-542.
  9. Zhang S, Wang Y, Xie W, et al. Squaramide-based synthetic chloride transporters activate TFEB but block autophagic flux[J]. Cell Death & Disease, 2019, 10(4). First author
  10. Zhang S, Stoll G, San Pedro J M B, et al. Evaluation of autophagy inducers in epithelial cells carrying the ΔF508 mutation of the cystic fibrosis transmembrane conductance regulator CFTR[J]. Cell death & disease, 2018, 9(2): 191. First author
  11. Cheng W, Zhang S, Li Y, et al. Intestinal tuberculosis: clinico-pathological profile and the importance of a high degree of suspicion[J]. Tropical Medicine and International Health, 2019, 24(1):81-90. Co-first author
  12. Cheng W, Zhang S, Wang J, et al. Three-dimensional CT enterography versus barium follow-through examination in measurement of remnant small intestinal length in short bowel syndrome patients[J]. Abdominal Radiology, 2018: 1-8. Co-first author
  13. Zhang S, Ren L, Li Y, et al. Bacteriology and drug susceptibility analysis of pus from patients with severe intra-abdominal infection induced by abdominal trauma[J]. Experimental and therapeutic medicine, 2014, 7(5): 1427-1431. First author
  14. Yin J, Wang J, Zhang S, et al. Early versus delayed enteral feeding in patients with abdominal trauma: a retrospective cohort study[J]. European Journal of Trauma and Emergency Surgery, 2015, 41(1): 99-105.
  15. Wang J, Yao D, Zhang S, et al. Laparoscopic surgery for radiation enteritis[J]. journal of surgical research, 2015, 194(2): 415-419.
  16. Yin, J., Zhao, Z., Li, Y., Wang, J., Yao, D., Zhang, S., … & Li, J. (2014). Goal-directed transfusion protocol via thrombelastography in patients with abdominal trauma: a retrospective study. World Journal of Emergency Surgery, 9(1), 28.
  17. Yin, J., Wang, J., Yao, D., Zhang, S., Mao, Q., Kong, W., … & Li, J. (2014). Is It Feasible to Implement Enteral Nutrition in Patients With Enteroatmospheric Fistulae? A Single-Center Experience. Nutrition in Clinical Practice, 0884533614536587.
  18. Co-author of the book chapter Treatment Strategies and Techniques of Emergency Medicine (in Chinese), Shanghai Scientific and Technological Literature Press, January 1, 2023.
  19. Co-author of the book chapter Contemporary Short Bowel Syndrome Therapeutics (in Chinese), People’s Health Publishing House, September 1, 2022.