Core Equipment
| Location | Code | Equipment | Information |
| N22-5F | Confocal Microscope01 | Leica TCS SP8 Confocal Laser Scanning Microscope System 鐳射掃描共聚焦顯微系統 | *Laser 405 nm DMOD, 50mW，Laser 488nm, 20mW，Solid State Laser 552nm, 20mW，Solid State Laser 638nm, 20mW *PMT SP confocal detector for imaging，HyD SP GaAsP-Detector for gated imaging *This equipment is for use in open areas. Do not use infectious biological materials. |
| N22-7035a | Fluorescence microscope | Leica Dmi8 螢光顯微鏡 | Samples capable of recording BF, PH and fluorescent labelling, with a laser range of 390–680 nm |
| N22-7035a | Evident Fluorescence mic | Olympus IX83 Evident 螢光顯微鏡 | Featuring observation modes including BF, PH, DIC, and FL, and equipped with a high-resolution monochrome cooled digital camera specifically designed for microscopy. |
| N22-7039 | Confocal scanner | Leica Stellaris 5 with Dmi8 共聚焦螢光顯微鏡 | Observation methods including FL and DIC, equipped with a confocal scanner |
| N22-7039 | Leica – DMi8 microscope | Leica – DMi8 Inverted fluorescent microscope with Thunder System 螢光顯微鏡 | Featuring FL and DIC observation modes, paired with the Thunder system to provide stereoscopic and layered analysis methods. |
| Location | Code | Equipment | Information |
| N22-5F | Flow cytometer | BD LSRFortessa cytometry 流式細胞儀 | Equipped with three laser units, each capable of independent on/off control: 488nm, 640nm, 405nm. Enables sample analysis across 14 fluorescence channels. Simultaneously incorporates HTS technology for rapid detection of small sample volumes at high throughput. Fluorescence detection sensitivity reaches 80 MESF (FITC) and 30 MESF (PE), enabling precise detection of extremely weak signals. Coefficient of Variation (CV) <3%. Analysis speed: <20,000 cells per second. This apparatus is for use in open areas. Do not use infectious biological materials. |
| N22-5F | Flow cytometer | BD FACSARIA III Cell Sorter 流式分選儀 | Equipped with five lasers (375, 405, 488, 561, 640 nm), it enables simultaneous analysis of multiple fluorescent targets and can sort samples using nozzles of 70, 85, 100, or 130 µm for subsequent research as required. Sensitivity is <87 MESF/FITC and <29 MESF/PE. This equipment is for use in open areas. Do not use infectious biological materials. |
| N22-7035a | flowcytometer | Beckman Coulter Cytoflex flow cytometer 流式細胞儀 | Equipped with three lasers (488, 640 and 405 nm), it can simultaneously detect up to ten fluorescent targets. |
| Location | Code | Equipment | Remark | Information |
| N22-6037A | THERMO-GCMS | Thermo ISQ LT GC-MS System 氣相色譜質譜聯用儀(單四極桿質譜) | Scan range 1.2–1100 μm Suitable for volatile, thermally unstable small molecules | |
| N22-6005A | THERMO-MSQ+ | Thermo LC-MSQ plus Single Quadrupole Mass Spectrometer (with Ultimate 3000 RSLC) 液相色譜質譜聯用儀(單四極桿質譜) | Scan range 17–2000 m/z Simple molecular weight determination (to two decimal places) Suitable for simple, rapid qualitative analysis of small molecules | |
| N22-6017 | THERMO-TSQ9000 | Thermo TSQ9000 GC-MS/MS System 氣相色譜-三重四極桿質譜 | Headspace sampler | Scan range 1.2~1100u, 20,000 u/s Electron Ionization (EI), with Full scan, SIM, FS/SIM, timed acquisition (t-SIM), FS/t-SIM Suitable for volatile, thermally stable small molecules |
| N22-6017 | WATERS-QQQ-01 | Waters Xevo TQD UPLC-MSMS (with ACQUITY i-class UPLC) 液相色譜質譜聯用儀(三重四極桿質譜) | Scan range 2–2048 m/z Molecular weight determination (to two decimal places) Full Scan, Product/Precursor ion scan, SIR, MRM (MS/MS) Quantitative analysis of known multi-component mixtures | |
| N22-6017 | WATERS-QQQ-02 | Waters Xevo TQ-S micro UPLC-MSMS (with ACQUITY i-class PLUS UPLC) 液相色譜質譜聯用儀(三重四極桿質譜) | Scan range 2-2048 m/z 分子量測定(小數點後兩位) Full Scan, Product/Precursor ion scan, SIR, MRM (MS/MS) Known multi-component quantitative analysis | |
| N22-6036A | THERMO-ORBITRAP | Thermo LTQ Orbitrap XL with Dionex UltiMate 3000 Binary Rapid Separation LC (RSLC) System 液相色譜-線性離子阱式傅立葉轉換電場軌道阱多次質譜串聯系統 | High-resolution mass spectrometry Requires experience in liquid chromatography Operators must have at least six months’ experience to be eligible for operation | Scan range 50–2000 m/z Mass accuracy 1–3 ppm, 100,000 FWHM MSn 1–10 high-resolution multi-stage mass spectrometry scanning DIA Suitable for -Omics research, biological sample matrices |
| N22-6036A | WATERS-G2Si | Waters SYNAPT G2-Si HDMS (with Acquity UPLC i class and A7890 GC FID system) 高解析度離子淌度-四極桿飛行時間串聯質譜系統 | High-resolution mass spectrometry Requires experience in liquid chromatography Operators must have at least six months’ experience to be eligible for operation | 掃描範圍 20-100k m/z 質量精確度 1 ppm, 60,000 FWHM DIA, DDA, ion mobility, MSn 1~2 適用於組學研究, 生物樣品基質 |
| N22-6036A | WATERS-XS | Waters SYNAPT XS HDMS (with Acquity UPLC i-class, ESI and MALDI source) 高解析度離子淌度-四極桿飛行時間串聯質譜系統 | High-resolution mass spectrometry Requires experience in liquid chromatography Operators must have at least six months’ experience to be eligible for operation Additionally equipped with an ESI source (standard liquid-phase connection) and a MALDI source (MALDI requires separate training; must specify MALDI usage when booking, as ion source changeover takes time). | Scan range 20–100 k m/z Mass accuracy 1 ppm, 60,000 FWHM DIA, DDA, ion mobility, MSn 1–2 An upgraded version of G2Si, with largely similar functionality |
| N22-6013A | THERMO-ICPMS | Thermo iCAP Qs Inductive Coupled Plasma Mass Spectrometer ICP-MS 高性能四極杆感應耦合電漿質譜儀 | Elemental and heavy metal analysis | |
| N22-7024A | AB-QTRAP4000 | SCIEX 4000 Q TRAP LC/MS/MS System (with Agilent 1200 LC) 四極桿-線性離子阱質譜儀 | Scan range 5–2000 m/z Molecular weight determination (to two decimal places) Full Scan, Product/Precursor ion scan, SIR, MRM (MS/MS) Biological sample matrix | |
| N22-7024 | AB-TripleTOF 5600+ | SCIEX 5600+ TripleTOF LC/MS/MS System (With UPLC SCIEX ExionLC) 三重四極桿-飛行時間質譜儀 | Scan range 40 kDa TOF-MS mass resolution and acquisition speed ≥35,000 (FWHM) at 956 m/z, using 50 ms accumulation time TOF-MS/MS mass resolution and acquisition speed ≥25,000 (FWHM) at 195 m/z, and ≥18,000 (FWHM) at 86 m/z, using 50 ms accumulation time Biological sample matrix |
As pharmaceutical engineering equipment is installed within the GMP area on N22-8F, which constitutes a strictly controlled, isolated facility with specific operating protocols, external parties wishing to utilise such equipment should contact staff at the Macau Centre for R&D in Chinese Medicine and the N22-8F technicians for consultation.
| Location | Code | Equipment | Information |
| N22-8034F | MiniGLATT-Fluid Bed | Fluid Bed MINI-GLATT, GLATT GmbH, Germany 流化床 | Designed for experimental small-batch fluidisation, for drying, mixing, granulation, agglomeration, powder coating, pellet coating and micro-pellet coating. |
| N22-8034C | Glatt-TMG 1/6 | Vertical Granulator TMG 1/6, Glatt 實驗室型混合濕法造粒機 | Used for high-shear granulation of pharmaceutical raw materials. When drugs or drug-excipient mixtures are unsuitable for direct compression, the granulation process may be employed. |
| N22-8034C | Glatt-GS100 | GLATT ROTOR SIEVE – GS 100 篩分儀 | Used to homogenise dry products to a specified particle size. It is specifically designed to reduce oversized particles to the target dimension and to grind agglomerates back to their original size. |
| N22-8034O | SEPHA-EZ-Blister II | Laboratory Scale Blister Packaging Machine, Sepha EZ Blister II 實驗室型膠囊片劑封裝機 | Designed for laboratories and organisations requiring small-batch packaging solutions. Customisable blister packaging machines. |
| N22-8043G | Optimags Coating Machine | HH/Optimags (Germany) Coating Machine MBCD1.3 包膜儀 | The homogenised liquid formulation processed by the homogeniser may be applied via a coating apparatus onto pre-prepared membranes to produce membrane formulations. |
| N22-8034S | Glatt-GC1 | Glatt (Germany) Drum Coating System GC1 包衣鍋 | The coating pan applies a medicinal film to the surface of solid tablets or pills to alter their rate of drug release, serving as an essential tool for both pharmaceutical research and production. |
| N22-8046H | Becomix-RW2.5 | Becomix (Germany) Homogenizer RW2.5 均質儀 | The homogeniser uniformly blends extracts from medicinal raw materials containing active pharmaceutical ingredients with excipients, producing a homogeneous liquid suitable for subsequent pharmaceutical processes. Applicable to various liquid formulations including solutions, oils, emulsions, and suspensions, it serves as an essential tool for developing new liquid pharmaceutical products of diverse types. |
| N22-8034P | DottBonapace-INCAP | Dott Bonapace (Italy) Capsule Filler INCAP 膠囊灌裝機 | The capsule filling machine is a tabletop automated device capable of filling pre-prepared solid pharmaceuticals—such as micro-pills, micro-tablets, and powders—into capsules and compressing them into finished capsule formulations. It serves as a fundamental tool for both pharmacokinetic research and pharmaceutical production. |
| N22-8034N | Glatt-CML10 | Glatt (Germany) Blending Machine CML10 混合器 | The mixer is a small-scale development apparatus capable of uniformly blending dried powdered and granular Chinese herbal extracts with excipients. It permits free adjustment of mixing ratios, serving as an essential tool for both pharmaceutical research and production. |
| N22-8046D | Capmatic-PVR01 | Capmatic (Canada) Semi-Automatic Filling and Capping Machine PVR-01 半自動灌液及封蓋機 | The semi-automatic liquid filling and capping machine operates mechanically to semi-automatically or manually fill prepared medicinal solutions into bottles and seal the caps, thereby producing finished products. It serves as an essential tool within oral liquid production lines. |
| N22-8034C | Glatt-GSF100 | Glatt (Germany) Rotor Sieve GSF100 篩分儀 | The sieving apparatus homogenises solid pharmaceutical preparations, employing sieving principles to separate and collect particles of varying sizes. This ensures uniform particle size within the formulation, thereby stabilising the efficacy of the finished product. It serves as an essential instrument for pharmacokinetic research and the production of oral solid dosage forms. |
| N22-8046D | B+S-EDM3295 | B+S (Germany) Electrical Dosing Machine model EDM 3295 液體灌裝機 | The liquid filling machine operates as a semi-automatic mechanical device, dispensing pre-prepared medicinal solutions into bottles, syringes, and cartridges, among other customisable containers. This allows containers to be pre-designed and filled using this apparatus, thereby enhancing product development flexibility. It serves as an essential tool within oral liquid production lines. |
| N22-8050 | Instron-ASTM D882 | Instron (Canada) ASTM D882 Universal Tester (3342 single column tabletop model) 膜劑張力測定儀 | Film Tension Tester measures the tensile strength and toughness of materials such as oral film formulations and packaging films, serving to monitor and maintain product quality. It is an essential tool for quality control. |
| N22-8046D | B+S-HV510 | B+S (Germany) Closing machine for crimp caps and screw caps machine model HV 510 藥瓶封蓋機 | The bottle capping machine, designed to operate in conjunction with liquid filling machines, provides semi-automatic mechanical capping for containers already filled with pharmaceutical solutions. It serves as an essential tool within oral liquid production lines. |
| N22-8034H | Powtec-RCC | Powtec Dry Compactor RCC 乾法製粒機 | Primarily processes powdered materials into granules. This machine is suitable for research and development applications and can handle small-scale production. Production speeds can reach up to 10kg per hour. This machine is exceptionally easy to clean and can be thoroughly cleaned within minutes, as all major components—such as the feeder, compression rollers, and rotating shaft—feature a cantilever design. No tools are required when replacing machine parts. |
| N22-8034T | AckleyVIP | Ackley VIP Tablet/Capsule/Softgel Capsule Printer 片劑、膠囊、軟膠囊打印機 | Capsule printing apparatus. |
| N22-8034Q | Korsch-XP1 | Korsch Tablet Press XP-1 壓片機 | Assess the feasibility of products, screen and evaluate the characteristics of solid products. Capable of rapidly setting up and cleaning extremely small quantities of material within minimal timeframes. |
| N22-8034T | SANKO-FC80 | SANKO, FC-80, One-Lane Automatic Stick-type Packing Machine 全自動條狀包裝機 | Primarily used for the inner packaging (strip packaging) of oral solid granules, powders, and similar products. |
| N22-8034T | DottBonapace-SBP5 | DOTT Bonapace, SBP5, Double Soft Aluminum Packing/Strip Packing Machine 雙軟鋁包裝機 | Primarily used for the inner packaging (aluminium foil packaging) of oral solid granules, powders, and similar products. |
| Location | Code | Equipment | Remark | Information |
| N22-G012 | Bruker-NMR | Bruker AVANCE III HD 600MHz NMR Spectrometer 核磁共振光譜儀 (600 MHz) | Equipped with Cyroprobe and an autosampler | A technique for observing the dynamics of atomic nuclei within molecular structures, which determines molecular structure by analysing the spin characteristics of atomic nuclei. |
| Location | Code | Equipment | Information |
| N22-5F | STEDYCON | Abberior STEDYCON Microscopy System 高解析度納米級別生物大分子結構成像系統 | 1. 4-Channel confocal imaging system. Among those, 2 channels are for STED superresolution imaging. 2. All four detectors are Avalanche Photo diodes, single photo counting type 3. Time Correlated single photon counting FLIM and software 4. 775nm STED laser, pulse 5. 405nm excitation laser (continuous wavelength type) 6. 488nm, 561nm, 640nm pulsed excitation lasers 7. LED Fluorescence light source and bandpass filters for DAPI/GFP/Cy3/CY5 8. Fluorescence Phase-contrast Plan-Neofluar 10x/0.3 Ph1 (r = 0.92μm) 9. Fluorescence Phase-contrast Plan-Neofluar 20x/0.5 Ph2 (r = 0.55μm) 10. Confocal grade Plan-Apochromat 40x/0.95 (r = 0.29μm) 11. Confocal grade Plan-Apochromat 63x/1.40 Oil (r = 0.20μm) 12. Superresolution-grade Alpha Plan-Apo 100x/1.46 Oil (r = 0.19μm) 13. CMOS camera. 5MP color and imaging software 14. Huygens Deconvolution software for STEDYCON (both confocal and STED images) • The STED resolution of this system can reach 40nm (X-Y axis), while confocal resolution can reach 200nm, depending on dyes and when using 100x/1.46 objective lens • For best performance in STED measurements, it is recommended to use glass coverslips with a thickness of 170 µm (No 1.5 or No 1.5H). •This equipment is for use in open areas. Do not use infectious biological materials. |
| N22-5F | OPP-HCS | Opera Phenix Plus High-Content Screening System 高內涵細胞成像 | ● Speed: 12 mins / 4 channels / 4 field-of-view per well / 96-well plate (est. 0.47s each view) ● CMOS camera ● Air objectives and Water immersion objectives are available (10x air, 20x air, 20x water, 40x air, 40x water, 63x water(NA 1.15, WD 0.6 mm)) ● Confocal spinning disk technology is available ● Experimental automation ●This equipment is for use in open areas. Do not use infectious biological materials. |
| N22-7035a | QPCR | ABI QS7 Flex 即時聚合酶連鎖反應儀 | 96-well or 384-well reaction plates with 0.1 ml and 0.2 ml volumes |
| N22-7035a | BC-MAX XP centrifuge | Beckamn Coulter – Optima MAX-XP Ultracentrifuge 超高速離心機 | The rotor compatible with the MLA-130 achieves 130,000 RPM for centrifuging 1 ml or 2 ml samples. Specialised ultracentrifuge tubes must be prepared by user for use with this rotor. |
| N232-6002 | Beckman-XPN100 | Beckman Coulter XPN-100 Ultracentrifuge 超高速離心機 | Equipped with Type 90 Ti, Type 19, SW41 Ti, and Type 45 Ti rotors available for loan. Users must provide their own ultracentrifuge-specific centrifuge tubes. This ultracentrifuge is commonly used for preparing chemical reagents. Its use is not recommended for biological samples sensitive to contamination sources. |