Email

cmchong@um.edu.mo

Tel

(853) 8822-4512

Office

N22-7014

Consultation Hours

Tue: 16:30-17:30
Thu: 16:30-17:30

Cheong Meng CHONG 鍾昌明

Assistant Professor

Academic Qualifications

  • Postdoctoral training, National University of Singapore, Singapore
  • Ph.D., University of Macau, Macau

Teaching

CMED8003Functional Food Product Development in Chinese Medicine
CMED7009Development of Drugs and Health Product
CMED7001Pharmacology and Safety Evaluation
HSCI3000Neuroscience and Neurodegenerative Diseases

Research Interests

  1. Understanding the molecular basis of cellular pathology in aging-associated diseases.
  2. Drug discovery for the treatment of aging-associated diseases.

We are looking for Ph.D. students and master students who are interested in neuropharmacology. For further information, please contact Dr. Chong via email (cmchong@um.edu.mo).

# (co-)corresponding author

  1. Yen YH, Yuan F, Tang D, Luo JF, Ming C, Kang PJ, Su H, Chong CM#, Zhang SC. APP deficiency ameliorates FAD Presenilin 1 F105C and A246E mutations-induced mitochondrial dysfunction in human cortical neurons. International Journal of Biological Sciences. 2026. 22(5):2720-2735.
  2. Qu S, Tang D, Fan L, Dai Y, Zhong HJ, Cai W, Chong CM#. P-hydroxybenzaldehyde from Gastrodia elata Blume reduces hydroxyurea-induced cellular senescent phenotypes in human SH-SY5Y cells via enhancing autophagy. Pharmaceuticals. 2026. 19(2):207.
  3. Wang D, Tang D, Zhang Q, Chen S, Zhao G, Chong CM#. Azoramide attenuates thapsigargin-induced ER stress and cell death in human SH-SY5Y cells via maintaining intracellular calcium homeostasis. European Journal of Pharmacology. 2025. 1007:178299.
  4. Yu R, Ai N, Huang C, Wang D, Bian C, Ge W, Chong CM#. Aspirin reduces Ponatinib-induced cardiovascular toxic phenotypes and death in zebrafish. Biomedicine & Pharmacotherapy. 2024. 180:117503.
  5. Lu C, Zhang S, Lei SS, Wang D, Peng B, Shi R, Chong CM#, Zhong Z, Wang Y. A comprehensive review of classical prescription Yiguan Jian: Phytochemistry, Quality Control, Clinical applications, Pharmacology, and Safety. Journal of Ethnopharmacology. 2024. 319:117230.
  6. Wang D, Qu S, Zhang Z, Tan L, Chen X, Zhong HJ, Chong CM#. Strategies targeting endoplasmic reticulum stress to improve Parkinson’s disease. Frontiers in Pharmacology. 2023. 14: 1288894.
  7. Ai N, Wang D, Qu S, Vong CT, Yuan M, Su H, Ge W, Chong CM#. Azoramide prevents MPP+-induced dopaminergic neuronal death via upregulating ER chaperone BiP expression. Free radical biology and medicine. 2023. 208:299-308.
  8. Chou SM, Yen YH, Yuan F, Zhang SC, Chong CM#. Neuronal senescence in the aged Brain. Aging and disease. 2023. 14(5):1618-1632.
  9. Lu C, Qu S, Zhong Z, Luo H, Lei SS, Zhong HJ, Su H, Wang Y, Chong CM#. The effects of bioactive components from the rhizome of Gastrodia elata Blume (Tianma) on the characteristics of Parkinson’s disease. Frontiers in Pharmacology. 2022. 13:963327.
  10. Chong CM, Tan Y, Tong J, Ke M, Zhang K, Yan L, Cen X, Lu JH, Yao X, Chen G, Su H, Qin D. Presenilin-1 F105C mutation leads to tau accumulation in human neurons via the Akt/mTORC1 signaling pathway. Cell & Bioscience. 2022. 2(1):131.
  11. Chong CM, Zhong Z, Vong CT, Wang S, Lu JJ, Zhong HJ, Su H, Wang Y. The potentials of Uncariae Ramulus Cum Uncis for treatment of migraine: Targeting CGRP in the trigeminovascular system. Current Neuropharmacology. 2020;19(7):1090-1100.
  12. Ke M*, Chong CM*, Zhu Qi, Zhang K, Cai CZ, Lu J, Qin D, Su H. Comprehensive perspectives on experimental models for Parkinson’s disease. Aging and Disease. 2021. 12(1):223-246. (Co-first author).
  13. Ke M*, Chong CM*, Zeng H, Huang M, Huang Z, Zhang K, Cen X, Lu J, Yao X, Qin D, Su H. Azoramide protects iPSC-derived dopaminergic neurons with PLA2G6 D331Y mutation through restoring ER function and CREB signaling. Cell Death and Disease. 2020. 11(2):130. (Co-first author).
  14. Ke M*, Chong CM*, Su H. Using induced pluripotent stem cells for modeling Parkinson’s disease. World Journal of Stem Cells. 2019. 11(9):634-649. (Co-first author).
  15. Chong CM, Su H, Lu JJ, Wang Y. The neuroprotective effects of bioactive components from rhizome of Salvia miltiorrhiza (Danshen) on Alzheimer’s disease. Chinese Medicine. 2019. 14:19.
  16. Chong CM, Ke M, Tan Y, Huang Z, Zhang Z, Ai N, Ge W, Qin D, Lu JH, Su H. Presenilin 1 deficiency suppresses autophagy in human neural stem cells through reducing γ-secretase-independent ERK/CREB signaling. Cell Death and Disease. 2018. 9(9):879.
  17. Chong CM, Ai N, Lee MY. ROCK in CNS: different roles of isoforms, and therapeutic target for neurodegenerative disorders. Current drug targets. 2017. 18(4):455-462.
  18. Chong CM, Ai N, Ke M, Tan Y, Huang Z, Lu JH, Ge W, Su H. Roles of nitric oxide synthase isoforms in neurogenesis. Mol Neurobiol. 2017. 55(3):2645-2652.
  19. Chong CM, Ma D, Zhao C, Franklin RJ, Zhou ZY, Li C, Ai N, Yu H, Hou T, Sa F, Lee MY. Discovery of a novel neuroprotectant, BHDPC that protects against MPP+-induced neuronal death in multiple experimental models. Free radical biology and medicine. 2015. 89:1057-1066.
  20. Chong CM, Shen MG, Zhou ZY, Pan P, Hoi PM, Li S, Wang L, Ai N, Zhang LQ, Li CW, Yu HD, Hou TJ, Lee MY. Discovery of a benzofuran derivative (MBPTA) as a novel ROCK inhibitor in protecting against MPP+-induced oxidative stress and cell death in SH-SY5Y cells. Free radical biology and medicine. 2014. 74:283-93.
  21. Chong CM, Zhou ZY, Valentina RN, Cui GZ, Zhang LQ, Sa F, Hoi PM, Kevin C, Lee MY. Danshensu protects against 6-hydroxydopamine-induced damage of PC12 cells in vitro and dopaminergic neurons in zebrafish. Neuroscience Letters. 2013. 543:121-5.
  22. Chong CM, Gao S, Chiang BY, Hsu WH, Lin TC, Chen TC, Lin CH. An acyloxymethyl ketone-based probe to monitor the activity of glutathionylspermidine amidase in Escherichia coli. ChemBioChem. 2011. 12(15):2306-09.
  23. Pai CH, Chiang BY, Ko TP, Chou CC, Chong CM, Yen FJ, Chen S, Coward JK, Wang AH, Lin CH. Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase. EMBO J. 2006. 25(24):5970-82.

  • Young Editorial Consultant of Chinese Medicine
  • Director of Macau Life Sciences Institute (MLSI)
  • The permanent member of Macau Laboratory Technologist Association (MLTA)