Email

zfzhong@um.edu.mo

Tel

(853) 8822-4676

Office

N22-8014

Consultation Hours

Tue: 10:00-12:00

Thu: 15:00-17:00

Zhangfeng ZHONG 鍾章鋒

Assistant Professor

Academic Qualifications

  • D.Phil. in Biomedical Sciences, University of Macau, Macao SAR, China
  • M.Sc. in Chinese Medicinal Science, University of Macau, Macao SAR, China
  • B.Sc. in Pharmacy, Guangdong Medical University, China
  • Visiting Scholar, Northwestern University, USA

Teaching

HSCI1006Organic Chemistry LaboratoryB.Sc. Course
HSCI3012Pharmaceutical AnalysisB. Sc. Course
CMED7017Across the Gap between Science and IndustryM.Sc. Course
CMED7006Introduction to Research in Medical AdministrationM.Sc. Course
CMED7030Introduction to Medicinal AdministrationM.Sc. Course

Research Interests

Research Interests

  • Study of Plant-derived exosome like vesicles.
  • Research and development of Chinese medicine.
  • Discovery and application of natural products.
  • Drug screening and lead compound analysis.

Dr. ZHONG’s group welcome MSc and PhD students, research assistants and postdocs in the field of Chinese medicine, natural products, and extracellular vesicles. Interested people could contact Dr. ZHONG at zfzhong@um.edu.mo with a complete curriculum vitae.

Representative peer-reviewed journal papers (h-index 39)

[1] Shi R, Tan W, Jin H, Chan S, Li W, Lei S, Cui G, Wang Y, Yang D, Zhong Z. MicroRNA-enriched Plant-derived Exosomes Alleviates Colitis by Modulating Systemic Immunity, Metabolic Homeostasis, and Gut Microbiota.  Adv Sci. 2025, in press.

[2] Han X, Zheng W, Sun Z, Luo T, Li Z, Lai W, Jing M, Kuang M, Su H, Tan W, Zhong Z. Plant-derived exosomes: Unveiling the similarities and disparities between conventional extract and innovative form. Phytomedicine. 2025, 145:157087.

[3] Shi R, Chan SI, Jin H, Li W, Zhang L, Yang J, Wang R, Zheng X, Cui G, Zhong Z. Jiegeng Gancao Decoction Ameliorates Ulcerative Colitis: An Integrative Approach Combining Network Pharmacology and Proteomics via in silico and in vivo studies. Phytomedicine. 2025, 145:156972.

[4] Cui D, Zhang C, Zhang L, Zheng J, Wang J, He L, Jin H, Kang Q, Zhang Y, Li N, Sun Z, Zheng W, Wei J, Zhang S, Feng Y, Tan W, Zhong Z. Natural anti-cancer products: insights from herbal medicine. Chin Med. 2025, 20:82.

[5] S Chen, C Shen, W Li, Y Fan, DH Yang, Y Wang, R Feng, G Li, Z Zhong. Recent Advances in Bioactivity-Guided Drug Screening Strategies for Pre-Clinical and Clinical Drug Discovery. Trends Analyt Chem. 2024, 181: 118042.

[6] Huang J, Shi R, Chen F, Tan HY, Zheng J, Wang N, Li R, Wang Y, Yang T, Feng Y, Zhong Z. Exploring the anti-hepatocellular carcinoma effects of Xianglian Pill: Integrating network pharmacology and RNA sequencing via in silico and in vitro studies. Phytomedicine. 2024, 133:155905.

[7] Chan KI, Zhang S, Li G, Xu Y, Cui L, Wang Y, Su H, Tan W, Zhong Z. MYC Oncogene: A Druggable Target for Treating Cancers with Natural Products. Aging Dis. 2024, 15:640-697.

[8] Zhong Z, Vong CT, Chen F, Tan H, Zhang C, Wang N, Cui L, Wang Y, Feng Y. Immunomodulatory potential of natural products from herbal medicines as immune checkpoints inhibitors: helping to fight against cancer via multiple targets. Med Res Rev. 2022, 42:1246.

[9] Zhu Z, Cui L, Yang J, Vong CT, Hu Y, Xiao J, Chan G, He Z, Zhong Z. Anticancer effects of asiatic acid against doxorubicin-resistant breast cancer cells via an AMPK-dependent pathway in vitro. Phytomedicine. 2021, 92:153737.

[10] Sun Y, Wei J, Zou J, Cheng Z, Huang Z, Gu L, Zhong Z, Li S, Wang Y, Li P. Electrochemical detection of methyl-paraoxon based on bifunctional nanozyme with catalytic activity and signal amplification effect. J Pharm Anal. 2021, 11:653.

  1. Zhong Z. Modern technology for monitoring cancer metastasis in Chinese medicine. In: Modern technology and progress on anti-tumor Chinese medicine. YT Wang ed., People’s Medical Publishing House, Beijing, 2012. (ISBN: 978-7-117-16227-2).

  1. The Science and Technology Development Fund (FDCT), Grant no: 0047/2025/ITP1, Deciphering the Molecular Code of Centella asiatica Exosomes in Intervening Inflammation-Cancer Transformation Based on the Cross-Kingdom Regulatory Network of Plant-Derived miRNAs (PI), 2025-2026
  2. The Science and Technology Development Fund (FDCT), Grant no: 0008/2023/RIC, The Research and Development of Chinese Medicine for Drug Registration in Macao (PI), 2024-2027
  3. The Science and Technology Development Fund (FDCT), Grant no: 0123/2022/A, Research and development of Chinese classical prescription Wuzhuyu Decoction (PI), 2023-2026
  4. The Research Fund of University of Macau, Grant no: MYRG-GRG2023-00198-ICMS, Exploring the effect of Rosa roxburghii Tratt in reshaping intestinal microenvironment and delaying inflammation-cancer transformation of colitis-associated cancer via the TLR4/MyD88 and REG3g pathways (PI), 2024-2025
  5. The Research Fund of University of Macau, Grant no: SRG2022-00052-ICMS, Study on the effects of EUODIAE FRUCTUS- JUJUBAE FRUCTUS drug pair in the transformation of inflammation into cancer (PI), 2022-2025

  1. Zhong Z, Shi R, Li W, et al. Use of Centella asiatica exosomes in the preparation of drugs for the treatment of colitis. 2024, Chinese Invention Patents, 202410779535.7.
  2. Zhong Z, Shi R, He S, et al. A decoction device developed for Chinese classical prescriptions. 2023, Chinese Invention Patents, 202310897944.2.
  3. Zhong Z, Chen S, Jin H, et al. A quality testing method for Perillae fructus dispensing granules. 2024, Chinese Invention Patents, 202410570559.1.
  4. Wang Y, Zhong Z, Wang S, Shao S, Chen W. Application of Chinese medicine compound composition in preventing and improving Alzheimer’s disease. 2023, Chinese Invention Patents, CN 114272354 B.
  5. Wang Y, Chen Y, Zhong Z, Wang S, Vong C. Chinese medicine-loaded nanoparticles for the treatment of migraine and preparation method and application thereof. 2023, Chinese Invention Patents, CN 113827563 B.
  6. Wang Y, Chen W, Wang S, Zhong Z, Yu H. A medicinal and edible Baoyuan efferverscent tablets for enhancing immunity, and its preparation method. Chinese Invention Patents, CN114377105A. 2022

  • 2020, First Prize of International Award for Contribution to Chinese Medicine-Achievement Award in Medical Science
  • 2018, Hong Kong Scholars Award
  • 2012, Macao’s Scientific and Technological R&D Award for Postgraduates

  • Member, Chinese Pharmacological Society
  • Council, International Society for Chinese Medicine
  • Council, Word Federation of Chinese Medicine Societies

  • Guest Editor of Chinese Medicine (2023-)
  • Guest Editor of Molecules (2022-)
  • Guest Editor and Associate Editor of Frontiers in Immunology (2022-)
  • Youth Editorial Member of Chinese Medicine (2017-)
  • Review Editor of Frontiers in Pharmacology (2020-)
  • Project Executive of International Society for Chinese Medicine (2018-)
  • Ad-hoc reviewer of more than 10 peer-reviewed academic journals, including Molecular Cancer, Drug Resistance Updates, eBioMedicine, Frontiers in Immunology, Phytomedicine, Phytotherapy Research, European Journal of Pharmacology, Journal of Ethnopharmacology, and Chinese medicine.